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James Grau

James Grau
Mary Tucker Currie Professor
Areas of Speciality
  • Behavioral & Cellular Neuroscience
Memberships
Contact
  • (979) 845-2584
  • j-grau@tamu.edu
  • ILSB 3149A
Professional Links
Office Hours
Tuesday & Thursday 2:00pm-3:30pm subject to change
Rank
Mary Tucker Currie Professor

Research Interests

Learning, neural plasticity, pain, and the recovery of function after neural injury.

Dr. Grau’s research has focused on a number of topics, including learning, pain modulation, and the recovery of function after spinal cord injury. One line of work has examined whether lower level neural systems within the spinal cord can learn. His work has provided evidence that neurons within the spinal cord are sensitive to both temporal and behavioral relations. Interestingly, this learning appears to involve many of the same neurochemical systems that mediate learning and memory within the brain. More recently, his laboratory has been exploring the implications of these studies for the recovery of function after neural injury. Current research has shown that pain input after injury can increase tissue loss, undermine the recovery of function, and foster the development of chronic pain. Funded by both the Neilsen Foundation and NIH, his laboratory is seeking new treatments to promote recovery and treat pain after injury.

Recent Publications

Lee, K. H., Huang, Y.-J., & Grau, J. W. (2016). Learning about time within the spinal cord II: Evidence that temporal regularity is encoded by a spinal oscillator. Frontiers in Behavioral Neuroscience, 10:14. doi: 10.3389/fnbeh.2016.00014

Hansen, C. N., Faw, T. D., Kerr, S. C., Fisher, L. C., Deibert, R. J., White, S., Buford, J. A., Grau, J. W., & Basso, M. (2016). Sparing of descending systems rescues interneuron plasticity in the lumbar cord to allow adaptive learning after thoracic spinal cord injury. Frontiers in
Neuroscience, 10, 11. doi: 10.3389/fncir.2016.00011

Huang, Y.-J., Lee, K. H., Murphy, L., Garraway, S. M., & Grau, J. W. (2016). Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization. Experimental Neurology, 285, 82-95.

Khaing, Z. Z., Park, J., Shangjing, X., Agrawal, N. K., Plumton, G., Lee, K. H., Huang, Y.-J., Niemerski, A. L, Schmidt, C. E., Grau, J. W. (2016). Localized and Sustained Release of BDNF from Injectable Hydrogel/Microparticle Composites Fosters Spinal Learning after SCI. Journal of
Materials Chemistry B, 4, 7560-7571.

Turtle, J. D., Strain, M. M., Aceves, M., Huang, Y.-J., Reynolds, J. A., Hook, M. A., & Grau, J. W. (2017). Pain input impairs recovery after spinal cord injury: Treatment with lidocaine. Journal of Neurotrauma, 34, 1200-1208.

Grau, J. W., Huang, Y.-J., Turtle, J. D., Strain, M. M., Miranda, R. M., Garraway, S. M., & Hook, M. A. (2017). When pain hurts: Nociceptive stimulation induces a state of maladaptive plasticity and impairs recovery after spinal cord injury. Journal of Neurotrauma, 34, 1873-1890.

Huang, Y.J., Lee, K. H., Murphy, L., Garraway, S. M., & Grau, J. W. (2017). Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization. Experimental Neurology, 288, 38-50.

Baumbauer, K. M., Turtle, J. D., & Grau, J. W. (2017). Fixed spaced stimulation restores adaptive plasticity within the spinal cord: Identifying the eliciting conditions. Physiology & Behavior, 174, 1-9.